![]() Our results demonstrated that the encapsulation of ICD-85 enhances its anti-proliferative effects. Moreover, caspase-8 assay analysis demonstrated that the ICD- 85 NPs induced a higher apoptotic rate in HeLa cells compared to free ICD-85. The results also indicate that ICD-85-induced apoptosis on HeLa cells is associated with the activation of caspase-8. However, LDH assay demonstrated that ICD-85 has dose-dependent cytotoxicity on HeLa cells while ICD-85 NPs exhibited weaker cytotoxicity on same cells. The IC 50 value at 72 h was reduced from 25 ± 2.9 μg/mL for free ICD-85 to 15.5 ± 2.4 μg/mL for ICD-85 NPs. The MTT assay showed that ICD-85 NPs could enhance the in-vitro cytotoxicity against HeLa cells compared to the free ICD-85. The apoptotic effect of free ICD-85 and ICD-85 NPs on HeLa cells was assessed using caspase-8 colorimetric assay. The cytotoxicity was evaluated by MTT and LDH assays. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.The biological application of nanoparticles (NPs) is a rapidly developing area of nanotechnology that raises new possibilities in the treatment of human cancers. ( en Inventor Mark Edward Ruppen Yu-Fen Wang Sam Mattackal George Original Assignee Wyeth Priority date (The priority date is an assumption and is not a legal conclusion. Google Patents Compositions substantially free of galactomannan containing piperacillin and tazobactamĭownload PDF Info Publication number WO2005074925A1 WO2005074925A1 PCT/US2005/003048 US2005003048W WO2005074925A1 WO 2005074925 A1 WO2005074925 A1 WO 2005074925A1 US 2005003048 W US2005003048 W US 2005003048W WO 2005074925 A1 WO2005074925 A1 WO 2005074925A1 Authority WO WIPO (PCT) Prior art keywords piperacillin pharmaceutical composition tazobactam galactomannan composition according Prior art date Application number PCT/US2005/003048 Other languages French ( fr) Google Patents WO2005074925A1 - Compositions substantially free of galactomannan containing piperacillin and tazobactam WO2005074925A1 - Compositions substantially free of galactomannan containing piperacillin and tazobactam ![]()
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